HitPredict

Interactor 1: LRC8A (Q8IWT6)
Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)
Gene: LRRC8A

Interactor 2: LRC8A (Q8IWT6)
Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)
Gene: LRRC8A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.63 1.00 0.796

The method score is based on:

Property Details
Experiments 24790029, 30127360, 30095067
Identification Methods anti tag coimmunoprecipitation, electron microscopy 3D single particle reconstruction, 3D electron microscopy
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains LRR_8~LRR_8, Pannexin_like~Pannexin_like
Common GO terms GO:0001678 - intracellular glucose homeostasis
GO:0002329 - pre-B cell differentiation
GO:0005225 - volume-sensitive anion channel activity
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
and 17 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 810
Hs

1 810
+ Mm
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+ Hs
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+ Mm
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+ Zm
+ Hs
+ At
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+ At

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Last updated: 15 Jul 2024