HitPredict

Interactor 1: LMTK2 (Q8IWU2)
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)
Gene: LMTK2

Interactor 2: PPM1K (Q8N3J5)
Protein phosphatase Mn(2+)-dependent 1K (EC 3.1.3.16) (Branched-chain alpha-ketoacid dehydrogenase phosphatase) (BCKDH) (BDP) (EC 3.1.3.52) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C family member) (Protein phosphatase 2C isoform kappa) (PP2C-kappa) ([3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase, mitochondrial)
Gene: PPM1K

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1503 Hs			1 372
+	Hs
		728631 LMTK2_HUMAN (1-1503): 0: 1232: 100.00		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		1219443 LMTK2_HUMAN (1-1503): 0: 1232: 100.00		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		1168387 LMTK1_HUMAN (14-1500): 0: 702: 29.02		PPM1K_HUMAN (1-372): 1.48e-158: 451: 100.00
+	Hs
		728626 LMTK1_HUMAN (14-1500): 0: 702: 29.02		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		273446 LMTK1_HUMAN (14-1500): 0: 702: 29.02		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		1168415 LMTK1_HUMAN (14-1500): 0: 702: 29.02		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		728610 ERBB4_HUMAN (17-748): 3.15e-132: 444: 18.30		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		273436 ERBB4_HUMAN (17-748): 3.15e-132: 444: 18.30		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Zm
		4976 A0A1D6IZ90_MAIZE (1-436): 2.96e-129: 417: 18.58		A0A1D6DVE9_MAIZE (43-348): 2.02e-102: 307: 28.48
+	Hs
		601473 FGFR2_HUMAN (33-454): 4.84e-123: 406: 20.31		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Dm
		87959 D3DMF6_DROME (123-864): 3.32e-125: 416: 18.27		Q961C5_DROME (75-362): 4.28e-99: 300: 27.21
+	Hs
		273355 FGFR1_HUMAN (36-471): 9.49e-119: 395: 21.20		PPM1B_HUMAN (72-362): 1.82e-98: 302: 27.19
+	Hs
		665159 EPHA2_HUMAN (81-437): 8.15e-109: 371: 24.31		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		665259 EPHA2_HUMAN (81-437): 8.15e-109: 371: 24.31		PPM1L_HUMAN (94-355): 3.79e-92: 282: 31.88
+	Hs
		1071009 ERBB4_HUMAN (17-748): 3.15e-132: 444: 18.30		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		169202 MUSK_HUMAN (18-420): 2.36e-110: 373: 23.19		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		665427 EPHA3_HUMAN (55-410): 3.26e-109: 373: 22.84		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		665328 EPHA2_HUMAN (81-437): 8.15e-109: 371: 24.31		ILKAP_HUMAN (114-347): 8.95e-27: 111: 32.06
+	Hs
		411324 INSR_HUMAN (93-407): 2.85e-34: 145: 32.82		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94
+	Hs
		435562 IGF1R_HUMAN (131-399): 1.23e-33: 144: 33.33		PPM1A_HUMAN (72-362): 4.23e-103: 310: 27.94