HitPredict

Interactor 1: PSD12 (O00232)
26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)
Gene: PSMD12

Interactor 2: PSB3 (P49720)
Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)
Gene: PSMB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 456 Hs			1 205
+	Hs
		121944 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68
+	Hs
		121945 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSB5_HUMAN (8-197): 1.9e-66: 206: 22.63
+	Hs
		121930 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94
+	Hs
		121936 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA2_HUMAN (8-205): 1.92e-64: 200: 14.85
+	Hs
		121942 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA5_HUMAN (8-203): 6.92e-64: 199: 12.20
+	Hs
		121941 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSB9_HUMAN (6-200): 1.41e-63: 197: 23.08
+	Sc
		632509 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSB3_YEAST (3-205): 4.69e-66: 203: 54.19
+	Sc
		675446 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSB5_YEAST (8-195): 1.72e-64: 202: 23.40
+	Sc
		619991 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSB6_YEAST (2-205): 1.24e-60: 190: 21.17
+	Sc
		751186 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSB1_YEAST (8-197): 4.54e-56: 178: 22.11
+	Hs
		121707 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSB3_HUMAN (1-205): 1.02e-71: 218: 100.00
+	Hs
		121691 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSB6_HUMAN (7-200): 4.63e-70: 215: 22.68
+	Hs
		121692 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSB5_HUMAN (8-197): 1.9e-66: 206: 22.63
+	Dm
		771403 PSD11_DROME (28-443): 1.94e-86: 272: 15.21		PSB1_DROME (2-205): 3.62e-70: 215: 26.51
+	Hs
		121678 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSB1_HUMAN (2-205): 1.85e-65: 203: 23.94
+	Hs
		121684 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA2_HUMAN (8-205): 1.92e-64: 200: 14.85
+	Hs
		121689 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA5_HUMAN (8-203): 6.92e-64: 199: 12.20
+	Hs
		121688 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSB9_HUMAN (6-200): 1.41e-63: 197: 23.08
+	Dm
		1178939 PSD11_DROME (28-443): 1.94e-86: 272: 15.21		Q7K148_DROME (8-195): 1.2e-65: 205: 23.94
+	Dm
		47606 PSD11_DROME (28-443): 1.94e-86: 272: 15.21		A0AQH0_DROME (7-199): 4.68e-66: 204: 24.35