HitPredict

Interactor 1: RHG12 (Q8IWW6)
Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12)
Gene: ARHGAP12

Interactor 2: ABI2 (Q9NYB9)
Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Gene: ABI2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 846 Hs			1 513
+	Hs
		1219661 RHG12_HUMAN (1-846): 0: 802: 100.00		ABI1_HUMAN (1-513): 3.84e-97: 304: 61.00
+	Hs
		1219685 RHG12_HUMAN (1-846): 0: 802: 100.00		ASAP1_HUMAN (65-510): 8.77e-43: 165: 14.66
+	Hs
		924686 RHG12_HUMAN (1-846): 0: 802: 100.00		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		924608 Q1RLN5_HUMAN (1-846): 0: 759: 94.33		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		64747 RHG32_HUMAN (603-844): 6.16e-73: 263: 30.00		ABI2_HUMAN (1-513): 1.82e-91: 290: 100.00
+	Hs
		1021671 RHG21_HUMAN (78-846): 3.01e-97: 336: 21.24		MYO1E_HUMAN (325-508): 7.96e-32: 132: 22.68
+	Hs
		1052327 RHG35_HUMAN (392-844): 4.72e-71: 258: 19.72		SRC8_HUMAN (271-507): 2.78e-32: 131: 17.84
+	Hs
		548749 RGAP1_HUMAN (359-837): 1.26e-72: 252: 18.56		VAV_HUMAN (276-513): 8.6e-32: 131: 17.86
+	Hs
		1052250 RHG24_HUMAN (566-846): 3.02e-69: 245: 23.83		SRC8_HUMAN (271-507): 2.78e-32: 131: 17.84
+	Hs
		924798 ARAP1_HUMAN (223-844): 1.32e-74: 268: 16.02		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		64687 RHG32_HUMAN (603-844): 6.16e-73: 263: 30.00		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		1049716 SRGP1_HUMAN (526-845): 2.02e-70: 254: 21.61		ARHG7_HUMAN (451-508): 2.16e-18: 90.8: 41.38
+	Hs
		924893 RHG35_HUMAN (392-844): 4.72e-71: 258: 19.72		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		924852 RGAP1_HUMAN (359-837): 1.26e-72: 252: 18.56		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		200212 SRGP3_HUMAN (534-845): 2.27e-67: 245: 20.24		GRB2_HUMAN (454-510): 7.13e-18: 84.5: 37.93
+	Hs
		253421 SRGP2_HUMAN (534-845): 1.45e-69: 251: 22.40		ITSN2_HUMAN (289-512): 5.53e-14: 77.2: 15.63
+	Hs
		253384 SRGP2_HUMAN (534-845): 1.45e-69: 251: 22.40		SH3R3_HUMAN (370-508): 3.57e-10: 64.7: 20.14
+	Mm
		1145001 RHG30_MOUSE (639-844): 1.01e-63: 234: 31.78		ITSN1_MOUSE (382-510): 5.11e-13: 74.1: 18.18
+	Hs
		1078833 RHG31_HUMAN (634-844): 5.53e-63: 233: 31.05		ITSN1_HUMAN (380-510): 4.82e-12: 71: 15.22
+	Mm
		1141138 BCR_MOUSE (632-819): 5.52e-25: 114: 39.27		GRB2_MOUSE (454-510): 7.13e-18: 84.5: 37.93