HitPredict

Interactor 1: PSD12 (O00232)
26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)
Gene: PSMD12

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32235678
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 456 Hs			1 759
+	Hs
		1043195 CSN4_HUMAN (45-448): 2.23e-100: 307: 19.37		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		897245 CSN2_HUMAN (24-439): 1.11e-94: 294: 12.59		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043547 CSN4_HUMAN (45-448): 2.23e-100: 307: 19.37		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		897246 CSN2_HUMAN (24-439): 1.11e-94: 294: 12.59		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	At
		1258869 CSN2_ARATH (1-440): 3.83e-93: 290: 14.29		CUL3A_ARATH (36-759): 0: 853: 38.26
+	At
		1226048 CSN4_ARATH (24-451): 2.37e-87: 273: 16.13		CUL4_ARATH (24-759): 0: 861: 57.40
+	At
		1226058 CSN4_ARATH (24-451): 2.37e-87: 273: 16.13		CUL3A_ARATH (36-759): 0: 853: 38.26
+	Hs
		1042418 CSN4_HUMAN (45-448): 2.23e-100: 307: 19.37		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		897244 CSN2_HUMAN (24-439): 1.11e-94: 294: 12.59		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1041179 CSN4_HUMAN (45-448): 2.23e-100: 307: 19.37		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		897242 CSN2_HUMAN (24-439): 1.11e-94: 294: 12.59		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Mm
		897343 CSN2_MOUSE (24-439): 1.11e-94: 294: 12.59		CUL1_MOUSE (59-759): 0: 745: 30.55
+	At
		1258866 CSN2_ARATH (1-440): 3.83e-93: 290: 14.29		CUL1_ARATH (57-759): 0: 744: 34.20
+	Hs
		1041454 CSN4_HUMAN (45-448): 2.23e-100: 307: 19.37		CUL2_HUMAN (51-759): 0: 710: 27.00
+	At
		1226052 CSN4_ARATH (24-451): 2.37e-87: 273: 16.13		CUL1_ARATH (57-759): 0: 744: 34.20
+	Hs
		897243 CSN2_HUMAN (24-439): 1.11e-94: 294: 12.59		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Sp
		142919 CSN2_SCHPO (24-441): 1.96e-75: 244: 12.79		CUL1_SCHPO (62-759): 0: 680: 29.27
+	Hs
		1274036 CSN4_HUMAN (45-448): 2.23e-100: 307: 19.37		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Sc
		1014846 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		CDC53_YEAST (52-759): 0: 561: 21.90
+	Hs
		897289 CSN2_HUMAN (24-439): 1.11e-94: 294: 12.59		CUL5_HUMAN (59-759): 0: 589: 24.94