HitPredict - High confidence protein-protein interactions

Interactor 1: SLF2 (Q8IX21)
SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1)
Gene: SLF2

Interactor 2: SLF1 (Q9BQI6)
SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1)
Gene: SLF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.55	0.671

Property	Details
Experiments	26496610, 32389690, 33961781, 36373674
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000724 - double-strand break repair via homologous recombination GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response and 11 others more... GO:0016925 - protein sumoylation GO:0030915 - Smc5-Smc6 complex GO:0031334 - positive regulation of protein-containing complex assembly GO:0031625 - ubiquitin protein ligase binding GO:0032204 - regulation of telomere maintenance GO:0034184 - positive regulation of maintenance of mitotic sister chromatid cohesion GO:0035861 - site of double-strand break GO:0044877 - protein-containing complex binding GO:0140588 - chromatin looping GO:1990166 - protein localization to site of double-strand break GO:2000781 - positive regulation of double-strand break repair
Homologous interactions	0

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Last updated: 15 Jul 2024