HitPredict

Interactor 1: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Interactor 2: ULK4 (Q96C45)
Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4)
Gene: ULK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Hs			1 1275
+	Dm
		619793 MIRO_DROME (2-616): 0: 720: 47.21		FUSED_DROME (1-279): 1.04e-24: 113: 29.23
+	Hs
		545213 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		MARK3_HUMAN (3-702): 2.19e-167: 518: 15.07
+	Hs
		647855 RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22		MARK3_HUMAN (3-702): 2.19e-167: 518: 15.07
+	Hs
		647856 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		MARK3_HUMAN (3-702): 2.19e-167: 518: 15.07
+	Hs
		647896 RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70		MARK3_HUMAN (3-702): 2.19e-167: 518: 15.07
+	Hs
		545461 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		MARK2_HUMAN (3-702): 3.35e-156: 490: 14.75
+	Hs
		892447 RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22		MARK2_HUMAN (3-702): 3.35e-156: 490: 14.75
+	Hs
		894157 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		MARK2_HUMAN (3-702): 3.35e-156: 490: 14.75
+	Hs
		545358 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		ROCK1_HUMAN (2-754): 1.16e-130: 436: 15.22
+	Hs
		892353 RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22		ROCK1_HUMAN (2-754): 1.16e-130: 436: 15.22
+	Hs
		893975 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		ROCK1_HUMAN (2-754): 1.16e-130: 436: 15.22
+	Hs
		894319 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		MARK4_HUMAN (3-704): 1.38e-135: 434: 14.31
+	Hs
		330835 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		PAK4_HUMAN (1-283): 4.97e-25: 113: 29.37
+	Hs
		330930 RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22		PAK4_HUMAN (1-283): 4.97e-25: 113: 29.37
+	Hs
		894540 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		PAK5_HUMAN (1-283): 5.31e-26: 117: 32.17
+	Hs
		330933 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		PAK4_HUMAN (1-283): 4.97e-25: 113: 29.37
+	Hs
		894474 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		PAK6_HUMAN (7-279): 7e-25: 113: 29.35
+	Hs
		331013 RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70		PAK4_HUMAN (1-283): 4.97e-25: 113: 29.37
+	Dm
		54649 CDC42_DROME (3-172): 4.02e-76: 242: 25.00		APKC_DROME (1-281): 1.74e-24: 112: 27.91
+	Dm
		776946 CDC42_DROME (3-172): 4.02e-76: 242: 25.00		PAKM_DROME (2-283): 4.45e-24: 110: 28.77