HitPredict

Interactor 1: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Interactor 2: TRAK1 (Q9UPV9)
Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)
Gene: TRAK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	32877691, 33961781, 16630562, 24995978
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Hs			1 953
+	Hs
		1220736 MIRO1_HUMAN (1-618): 0: 763: 59.65		TRAK1_HUMAN (1-953): 0: 646: 100.00
+	Hs
		230511 MIRO2_HUMAN (1-618): 0: 792: 100.00		TRAK2_HUMAN (30-938): 5.22e-98: 330: 47.15
+	Hs
		230512 MIRO1_HUMAN (1-618): 0: 763: 59.65		TRAK2_HUMAN (30-938): 5.22e-98: 330: 47.15
+	Dm
		1213181 MIRO_DROME (2-616): 0: 720: 47.21		MILT_DROME (258-522): 2.53e-09: 63.3: 10.94
+	Hs
		545430 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		MRCKA_HUMAN (4-678): 5.5e-23: 108: 10.13
+	Hs
		892423 RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22		MRCKA_HUMAN (4-678): 5.5e-23: 108: 10.13
+	Hs
		894116 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		MRCKA_HUMAN (4-678): 5.5e-23: 108: 10.13
+	Hs
		1070238 RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70		MRCKA_HUMAN (4-678): 5.5e-23: 108: 10.13
+	Hs
		551652 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		DESP_HUMAN (38-579): 1.38e-20: 100: 10.28
+	Hs
		894128 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		MRCKG_HUMAN (23-365): 5.69e-20: 98.5: 15.43
+	Mm
		823529 CDC42_MOUSE (3-172): 5.67e-77: 244: 25.54		CTRO_MOUSE (31-512): 1.05e-18: 94.3: 10.72
+	Hs
		254462 RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22		ROCK2_HUMAN (155-590): 1.63e-16: 87: 11.53
+	Hs
		1070477 RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70		MYO5A_HUMAN (47-567): 2.47e-18: 93.1: 11.22
+	Hs
		545725 RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69		MRCKB_HUMAN (14-364): 3.56e-15: 82.6: 10.71
+	Hs
		725125 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		MYH10_HUMAN (9-491): 2.9e-17: 89.5: 10.79
+	Hs
		892702 RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22		MRCKB_HUMAN (14-364): 3.56e-15: 82.6: 10.71
+	Dm
		776947 CDC42_DROME (3-172): 4.02e-76: 242: 25.00		GEK_DROME (22-352): 3.4e-17: 89.3: 12.26
+	Hs
		894628 CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54		MRCKB_HUMAN (14-364): 3.56e-15: 82.6: 10.71
+	Hs
		254472 RHOG_HUMAN (3-170): 1.68e-74: 238: 27.47		ROCK2_HUMAN (155-590): 1.63e-16: 87: 11.53
+	Hs
		1070480 RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70		MRCKB_HUMAN (14-364): 3.56e-15: 82.6: 10.71