HitPredict

Interactor 1: MIRO1 (Q8IXI2)
Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1)
Gene: RHOT1

Interactor 2: PINK1 (Q9BXM7)
Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)
Gene: PINK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	22396657, 22078885
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0007005 - mitochondrion organization GO:0010821 - regulation of mitochondrion organization GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Hs			1 581
+	Hs
		1220647 MIRO2_HUMAN (1-618): 0: 764: 59.81		PINK1_HUMAN (1-581): 7.17e-159: 468: 100.00
+	Hs
		568729 MIRO2_HUMAN (1-618): 0: 764: 59.81		KAPCA_HUMAN (173-567): 1.06e-110: 336: 13.89
+	Dm
		1001802 MIRO_DROME (2-614): 0: 712: 50.94		PINK1_DROME (213-543): 1.29e-122: 379: 40.46
+	Hs
		1315495 RAB1B_HUMAN (5-172): 2.1e-71: 230: 21.77		PINK1_HUMAN (1-581): 7.17e-159: 468: 100.00
+	Hs
		900861 RHOA_HUMAN (6-186): 1.33e-65: 214: 23.59		PINK1_HUMAN (1-581): 7.17e-159: 468: 100.00
+	Hs
		783972 RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		545242 RAC2_HUMAN (3-185): 6.9e-70: 226: 23.86		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		783963 RAC3_HUMAN (3-168): 4.28e-70: 226: 23.89		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		783983 RHOG_HUMAN (3-170): 8.87e-68: 220: 25.28		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		681775 RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83		AKT1_HUMAN (115-573): 2.58e-118: 360: 12.89
+	Hs
		682177 RAB35_HUMAN (5-168): 1.96e-72: 233: 25.90		AKT2_HUMAN (115-573): 1.5e-117: 358: 12.66
+	Hs
		783965 RHOA_HUMAN (6-186): 1.33e-65: 214: 23.59		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		925221 RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83		KPCZ_HUMAN (54-568): 6.17e-114: 353: 13.97
+	Hs
		568619 RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83		KAPCA_HUMAN (173-567): 1.06e-110: 336: 13.89
+	Hs
		900405 RHOA_HUMAN (6-186): 1.33e-65: 214: 23.59		KPCZ_HUMAN (54-568): 6.17e-114: 353: 13.97
+	Rn
		88510 RHOA_RAT (6-186): 1.12e-65: 215: 23.59		D3Z9M9_RAT (1-244): 6.72e-116: 346: 77.46
+	Dm
		54649 CDC42_DROME (3-172): 2.18e-66: 217: 26.09		APKC_DROME (56-568): 3.79e-110: 343: 12.57
+	Hs
		568611 RHOA_HUMAN (6-186): 1.33e-65: 214: 23.59		KAPCA_HUMAN (173-567): 1.06e-110: 336: 13.89
+	Hs
		850632 RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83		KS6A3_HUMAN (154-555): 2.08e-92: 301: 16.59
+	Hs
		925229 RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83		DMPK_HUMAN (314-498): 7.75e-46: 172: 29.02