HitPredict

Interactor 1: SMC5 (Q8IY18)
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
Gene: SMC5

Interactor 2: SMC6 (Q96SB8)
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Gene: SMC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 11408570, 36373674, 37071682, 26496610, 32389690, 33961781, 18086888, 15601840
Identification Methods affinity chromatography technology, cross-linking study, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains AAA_23~SMC_N
Common GO terms GO:0000217 - DNA secondary structure binding
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000775 - chromosome, centromeric region
GO:0000781 - chromosome, telomeric region
and 18 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1101
Hs

1 1091
+ Hs
+ Sp
+ Hs
+ Hs
+ Sc
+ Sc
+ Hs
+ Sc
+ Hs
+ Ce
+ Sc
+ Mm
+ Sc
+ Sp
+ Sp
+ Xl
+ Hs
+ Ce
+ Sc
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024