HitPredict

Interactor 1: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	37071664
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1834 Hs			1 2442
+	Hs
		1222642 SLX4_HUMAN (1-1834): 0: 1486: 100.00		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Hs
		170418 SLX4_HUMAN (1-1834): 0: 1486: 100.00		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		631499 SLX4_HUMAN (1-1834): 0: 1486: 100.00		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		1056910 MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		1270755 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Mm
		70879 F8VPR5_MOUSE (884-1700): 1.05e-28: 128: 9.83		EP300_MOUSE (1-2426): 0: 867: 53.61
+	Hs
		554303 MUC1_HUMAN (1127-1735): 4.53e-16: 87: 11.22		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		998710 MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		998826 SRCAP_HUMAN (1206-1787): 5.26e-09: 64: 11.45		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		998940 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		801155 KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		1057027 MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Dm
		113976 M9PB30_DROME (1116-1784): 2.28e-27: 124: 8.45		M9PB30_DROME (244-1120): 3.23e-21: 104: 9.85
+	Hs
		1056838 MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		631425 MDC1_HUMAN (801-1763): 7.3e-12: 73.2: 9.54		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		170402 SRCAP_HUMAN (1206-1787): 5.26e-09: 64: 11.45		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		170437 CBP_HUMAN (885-1778): 4.86e-09: 64: 9.57		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		801437 KI67_HUMAN (889-1833): 3.44e-23: 110: 10.79		CHD7_HUMAN (70-467): 2.16e-11: 72.1: 9.68
+	Hs
		554259 MUC1_HUMAN (1127-1735): 4.53e-16: 87: 11.22		MUC1_HUMAN (1947-2441): 7.35e-18: 93.3: 11.02
+	Mm
		1351630 PCLO_MOUSE (826-1830): 1.25e-15: 85.9: 8.22		PCLO_MOUSE (1831-2420): 5.14e-13: 77.5: 10.91