HitPredict

Interactor 1: RN103 (O00237)
E3 ubiquitin-protein ligase RNF103 (EC 2.3.2.27) (KF-1) (hKF-1) (RING finger protein 103) (RING-type E3 ubiquitin transferase RNF103) (Zinc finger protein 103 homolog) (Zfp-103)
Gene: RNF103

Interactor 2: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 147
+	Hs
		122275 RN103_HUMAN (1-685): 0: 1271: 100.00		UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84
+	Hs
		122256 RN103_HUMAN (1-685): 0: 1271: 100.00		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		122263 RN103_HUMAN (1-685): 0: 1271: 100.00		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		122270 RN103_HUMAN (1-685): 0: 1271: 100.00		UB2E2_HUMAN (4-146): 1.76e-74: 222: 65.04
+	Hs
		122257 RN103_HUMAN (1-685): 0: 1271: 100.00		UB2E1_HUMAN (4-146): 2.18e-72: 216: 65.04
+	Hs
		122260 RN103_HUMAN (1-685): 0: 1271: 100.00		UBE2N_HUMAN (4-147): 3.74e-68: 204: 46.53
+	Hs
		196372 PJA2_HUMAN (526-685): 7.54e-34: 140: 21.71		UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84
+	Hs
		196282 PJA2_HUMAN (526-685): 7.54e-34: 140: 21.71		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		196294 PJA2_HUMAN (526-685): 7.54e-34: 140: 21.71		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		196289 PJA2_HUMAN (526-685): 7.54e-34: 140: 21.71		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		919792 PJA1_HUMAN (522-669): 3.07e-31: 131: 22.50		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		895852 PJA1_HUMAN (522-669): 3.07e-31: 131: 22.50		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		849362 DZIP3_HUMAN (469-680): 8.22e-27: 119: 20.09		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		919775 DZIP3_HUMAN (469-680): 8.22e-27: 119: 20.09		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		895840 DZIP3_HUMAN (469-680): 8.22e-27: 119: 20.09		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		1245284 PJA1_HUMAN (522-669): 3.07e-31: 131: 22.50		UB2E3_HUMAN (4-146): 1.05e-73: 220: 65.73
+	Hs
		196290 PJA2_HUMAN (526-685): 7.54e-34: 140: 21.71		UBE2N_HUMAN (4-147): 3.74e-68: 204: 46.53
+	Hs
		1205108 DZIP3_HUMAN (469-680): 8.22e-27: 119: 20.09		UB2E3_HUMAN (4-146): 1.05e-73: 220: 65.73
+	Hs
		851839 DZIP3_HUMAN (469-680): 8.22e-27: 119: 20.09		UB2E1_HUMAN (4-146): 2.18e-72: 216: 65.04
+	Hs
		896485 DZIP3_HUMAN (469-680): 8.22e-27: 119: 20.09		UBE2N_HUMAN (4-147): 3.74e-68: 204: 46.53