HitPredict

Interactor 1: ATOX1 (O00244)
Copper transport protein ATOX1 (Metal transport protein ATX1)
Gene: ATOX1

Interactor 2: ATP7A (Q04656)
Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein)
Gene: ATP7A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.786

Property	Details
Experiments	10497213, 12679332
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1-E2_ATPase~HMA, HMA~HMA, HMA~Hydrolase
Common GO terms	GO:0005507 - copper ion binding GO:0005829 - cytosol GO:0006825 - copper ion transport GO:0006878 - intracellular copper ion homeostasis GO:0032767 - copper-dependent protein binding and 1 others more... GO:1903136 - cuprous ion binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 68 Hs			1 1500
+	Hs
		122319 ATOX1_HUMAN (1-68): 5.78e-21: 79.1: 100.00		ATP7B_HUMAN (1-571): 2.75e-100: 355: 26.26
+	At
		1277663 ATOX1_ARATH (2-68): 7.6e-20: 76.4: 38.24		HMA5_ARATH (280-554): 4.04e-32: 138: 23.64
+	At
		287006 CCH_ARATH (2-65): 6.46e-18: 73: 38.46		HMA5_ARATH (280-554): 4.04e-32: 138: 23.64
+	At
		1277662 ATOX1_ARATH (2-68): 7.6e-20: 76.4: 38.24		HMA7_ARATH (1-308): 1.06e-23: 111: 10.59
+	At
		287005 CCH_ARATH (2-65): 6.46e-18: 73: 38.46		HMA7_ARATH (1-308): 1.06e-23: 111: 10.59
+	Sc
		751507 ATX1_YEAST (4-63): 1.33e-14: 62.9: 41.94		ATU2_YEAST (4-173): 9.71e-15: 81.8: 21.11