HitPredict

Interactor 1: UNC5B (Q8IZJ1)
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)
Gene: UNC5B

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 945 Hs			1 1620
+	Hs
		1077869 MYLK_HUMAN (37-133): 4.45e-11: 69.3: 13.00		ALK_HUMAN (1-1620): 0: 1883: 100.00
+	Hs
		434237 UNC5B_HUMAN (1-945): 0: 962: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		665628 UNC5B_HUMAN (1-945): 0: 962: 100.00		EPHB2_HUMAN (938-1436): 2.19e-123: 416: 23.26
+	Hs
		508096 UNC5B_HUMAN (1-945): 0: 962: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		411434 UNC5B_HUMAN (1-945): 0: 962: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435694 UNC5B_HUMAN (1-945): 0: 962: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		385149 UNC5B_HUMAN (1-945): 0: 962: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		1081529 UNC5B_HUMAN (1-945): 0: 962: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		306900 UNC5C_HUMAN (32-944): 0: 864: 63.75		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		411428 UN5CL_HUMAN (480-930): 1.15e-115: 366: 22.56		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		435688 UN5CL_HUMAN (480-930): 1.15e-115: 366: 22.56		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		434263 LRIG1_HUMAN (11-537): 2.34e-42: 170: 12.78		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Mm
		724165 LRIG1_MOUSE (1-561): 1.23e-43: 174: 12.94		RET_MOUSE (843-1477): 2.28e-128: 431: 23.21
+	Hs
		1070999 LRIG1_HUMAN (11-537): 2.34e-42: 170: 12.78		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		1070977 LRIG3_HUMAN (11-263): 1.61e-38: 157: 19.23		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Dr
		1126612 Q5J1R9_DANRE (2-477): 1.46e-19: 96.6: 10.60		Q5J1R9_DANRE (999-1386): 5.22e-111: 377: 31.72
+	Hs
		384706 ZO1_HUMAN (405-656): 2.76e-51: 198: 20.63		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		385273 PXDN_HUMAN (2-262): 8.33e-41: 165: 17.80		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Mm
		530201 NCAM1_MOUSE (49-293): 9.57e-24: 110: 14.23		NTRK2_MOUSE (1093-1379): 6.2e-64: 236: 41.22
+	Mm
		546312 AGRB3_MOUSE (173-327): 5.87e-12: 72.2: 21.97		NTRK2_MOUSE (1093-1379): 6.2e-64: 236: 41.22