HitPredict

Interactor 1: CDK20 (Q8IZL9)
Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42)
Gene: CDK20

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 346 Hs			1 303
+	Hs
		960345 CDK5_HUMAN (1-294): 2.23e-128: 370: 45.09		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Mm
		829611 CDK5_MOUSE (1-294): 2.54e-128: 370: 45.09		CHIP_MOUSE (1-303): 1.23e-67: 214: 97.37
+	Hs
		858651 CDK20_HUMAN (1-346): 2.32e-134: 387: 100.00		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Hs
		297042 CDK7_HUMAN (3-304): 2.01e-127: 370: 42.62		TOM70_HUMAN (4-212): 8.69e-40: 148: 22.47
+	At
		1106347 MPK4_ARATH (7-334): 3.11e-132: 383: 32.04		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	At
		1259046 MPK16_ARATH (3-335): 4.12e-129: 382: 32.75		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	At
		1106458 MPK5_ARATH (2-336): 7.68e-129: 375: 28.95		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	Mm
		829607 CDK5_MOUSE (1-294): 2.54e-128: 370: 45.09		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22