HitPredict

Interactor 1: CDK20 (Q8IZL9)
Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42)
Gene: CDK20

Interactor 2: CILK1 (Q9UPZ9)
Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK)
Gene: CILK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	16954377
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005929 - cilium and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 346 Hs			1 632
+	Hs
		415108 CDK1_HUMAN (1-292): 1.16e-131: 379: 42.18		CILK1_HUMAN (1-632): 0: 558: 100.00
+	Hs
		595751 CDK20_HUMAN (1-346): 2.32e-134: 387: 100.00		MAK_HUMAN (1-632): 2.41e-166: 490: 54.39
+	Hs
		625115 CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10		CDK2_HUMAN (1-290): 1.28e-143: 420: 38.91
+	Hs
		625363 CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10		CDK3_HUMAN (1-295): 6.17e-142: 416: 38.59
+	Hs
		625512 CDK20_HUMAN (1-346): 2.32e-134: 387: 100.00		CDK2_HUMAN (1-290): 1.28e-143: 420: 38.91
+	Hs
		414746 CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10		CDK1_HUMAN (1-289): 3.13e-136: 401: 39.93
+	Hs
		414864 CDK3_HUMAN (1-308): 3.83e-138: 395: 44.66		CDK1_HUMAN (1-289): 3.13e-136: 401: 39.93
+	Hs
		625365 CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10		CDK5_HUMAN (1-290): 1.44e-131: 389: 33.79
+	At
		1106192 CDKC2_ARATH (1-346): 5.1e-135: 395: 34.93		MPK3_ARATH (9-317): 7.94e-132: 393: 32.91
+	At
		1106234 CDKC1_ARATH (1-346): 1.98e-134: 394: 36.09		MPK3_ARATH (9-317): 7.94e-132: 393: 32.91
+	Zm
		1736 A0A096S009_MAIZE (2-335): 1.92e-128: 381: 31.20		A0A096S009_MAIZE (2-508): 9.36e-134: 406: 23.82
+	At
		1106290 MPK4_ARATH (7-334): 3.11e-132: 383: 32.04		MPK4_ARATH (7-330): 6.71e-136: 403: 32.33
+	Hs
		960080 CDK3_HUMAN (1-308): 3.83e-138: 395: 44.66		CDK5_HUMAN (1-290): 1.44e-131: 389: 33.79
+	At
		98290 F4JSF8_ARATH (1-343): 1e-130: 382: 31.78		F4JSF8_ARATH (1-467): 1.6e-133: 401: 39.96
+	Hs
		414679 CDK1_HUMAN (1-292): 1.16e-131: 379: 42.18		CDK1_HUMAN (1-289): 3.13e-136: 401: 39.93
+	Hs
		960308 CDK20_HUMAN (1-346): 2.32e-134: 387: 100.00		CDK5_HUMAN (1-290): 1.44e-131: 389: 33.79
+	Hs
		414865 CDK1_HUMAN (1-292): 1.16e-131: 379: 42.18		CDK17_HUMAN (1-289): 7.71e-59: 207: 38.49