HitPredict - High confidence protein-protein interactions

Interactor 1: IRAK3 (Q8K4B2)
Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)
Gene: IRAK3

Interactor 2: IRAK3 (Q8K4B2)
Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)
Gene: IRAK3

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12054681
Identification Methods	in-gel kinase assay
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	Death~Death, Pkinase~Pkinase
Common GO terms	GO:0000287 - magnesium ion binding GO:0001819 - positive regulation of cytokine production GO:0001960 - negative regulation of cytokine-mediated signaling pathway GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity and 28 others more... GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006468 - protein phosphorylation GO:0008063 - Toll signaling pathway GO:0009615 - response to virus GO:0010933 - positive regulation of macrophage tolerance induction GO:0010936 - negative regulation of macrophage cytokine production GO:0019221 - cytokine-mediated signaling pathway GO:0019901 - protein kinase binding GO:0032494 - response to peptidoglycan GO:0032496 - response to lipopolysaccharide GO:0032695 - negative regulation of interleukin-12 production GO:0032715 - negative regulation of interleukin-6 production GO:0032720 - negative regulation of tumor necrosis factor production GO:0034122 - negative regulation of toll-like receptor signaling pathway GO:0035556 - intracellular signal transduction GO:0042177 - negative regulation of protein catabolic process GO:0042803 - protein homodimerization activity GO:0043242 - negative regulation of protein-containing complex disassembly GO:0043244 - regulation of protein-containing complex disassembly GO:0043330 - response to exogenous dsRNA GO:0043407 - negative regulation of MAP kinase activity GO:0045824 - negative regulation of innate immune response GO:0046982 - protein heterodimerization activity GO:0070498 - interleukin-1-mediated signaling pathway GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1	609
Mm

1	609

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Last updated: 15 Jul 2024