HitPredict

Interactor 1: THOC6 (Q8L4M1)
THO complex subunit 6 (AtTHO6) (Protein DWD HYPERSENSITIVE TO ABA 1) (WD repeat-containing protein DWA1)
Gene: THO6

Interactor 2: CUL4 (Q8LGH4)
Cullin-4 (AtCUL4)
Gene: CUL4

Species: Arabidopsis thaliana

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20525848
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0009738 - abscisic acid-activated signaling pathway GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 367 At			1 792
+	Hs
		792982 LIS1_HUMAN (124-365): 1.24e-60: 202: 15.61		CUL4A_HUMAN (34-792): 0: 915: 55.79
+	Hs
		1043499 FBXW7_HUMAN (4-266): 1.29e-47: 173: 14.53		CUL4B_HUMAN (29-792): 0: 925: 55.95
+	Hs
		1043562 TBL1R_HUMAN (141-365): 2.56e-44: 161: 12.12		CUL4B_HUMAN (29-792): 0: 925: 55.95
+	Hs
		245601 TBL1X_HUMAN (131-361): 9.73e-44: 160: 13.53		CUL4B_HUMAN (29-792): 0: 925: 55.95
+	Hs
		1043385 SMU1_HUMAN (187-366): 6.14e-38: 144: 19.80		CUL4B_HUMAN (29-792): 0: 925: 55.95
+	Hs
		903209 WDR5_HUMAN (234-366): 3.29e-33: 127: 17.86		CUL4B_HUMAN (29-792): 0: 925: 55.95
+	At
		1114752 PRL1_ARATH (146-348): 3.89e-23: 102: 17.84		CUL4_ARATH (1-792): 0: 944: 100.00
+	Hs
		903208 WDR5_HUMAN (234-366): 3.29e-33: 127: 17.86		CUL4A_HUMAN (34-792): 0: 915: 55.79
+	Hs
		209433 PLRG1_HUMAN (39-313): 4.77e-53: 185: 20.58		CUL3_HUMAN (60-792): 0: 834: 38.63
+	Hs
		1042655 NLE1_HUMAN (2-273): 2.67e-50: 176: 13.74		CUL3_HUMAN (60-792): 0: 834: 38.63
+	Hs
		197016 PRP4_HUMAN (2-228): 1.15e-42: 157: 12.30		CUL3_HUMAN (60-792): 0: 834: 38.63
+	Hs
		1041692 SMU1_HUMAN (187-366): 6.14e-38: 144: 19.80		CUL3_HUMAN (60-792): 0: 834: 38.63
+	Hs
		1041647 TAF5_HUMAN (2-188): 2.66e-35: 138: 9.01		CUL3_HUMAN (60-792): 0: 834: 38.63
+	Hs
		903207 WDR5_HUMAN (234-366): 3.29e-33: 127: 17.86		CUL3_HUMAN (60-792): 0: 834: 38.63
+	Hs
		1042101 POC1B_HUMAN (2-174): 3.08e-22: 99.4: 13.87		CUL3_HUMAN (60-792): 0: 834: 38.63
+	Hs
		1041133 FBXW7_HUMAN (4-266): 1.29e-47: 173: 14.53		CUL1_HUMAN (93-792): 0: 758: 29.37
+	Hs
		903206 WDR5_HUMAN (234-366): 3.29e-33: 127: 17.86		CUL1_HUMAN (93-792): 0: 758: 29.37
+	Mm
		1257398 FBXW7_MOUSE (5-182): 2.46e-23: 103: 7.39		CUL1_MOUSE (93-792): 0: 758: 29.37
+	Sp
		142917 POF11_SCHPO (41-318): 1.32e-23: 103: 16.45		CUL1_SCHPO (95-792): 0: 686: 29.89
+	Sp
		142915 POF1_SCHPO (229-365): 1.05e-22: 101: 17.86		CUL1_SCHPO (95-792): 0: 686: 29.89