HitPredict

Interactor 1: CAND1 (Q8L5Y6)
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (AtCAND1) (Protein ENHANCER OF TIR1-1 AUXIN RESISTANCE 2) (Protein HEMIVENATA)
Gene: CAND1

Interactor 2: CUL1 (Q94AH6)
Cullin-1
Gene: CUL1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	17158585, 16045473, 15208391, 15208392, 18550827
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin~TIP120
Common GO terms	GO:0005634 - nucleus GO:0009733 - response to auxin GO:0010265 - SCF complex assembly GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1219 At			1 738
+	Hs
		1041947 CAND1_HUMAN (2-1219): 0: 796: 42.73		CUL3_HUMAN (1-738): 0: 796: 30.09
+	Hs
		1043084 CAND1_HUMAN (2-1219): 0: 796: 42.73		CUL4A_HUMAN (13-738): 0: 788: 34.61
+	Hs
		1043440 CAND1_HUMAN (2-1219): 0: 796: 42.73		CUL4B_HUMAN (12-738): 0: 774: 32.93
+	At
		1226075 CAND1_ARATH (1-1219): 0: 806: 100.00		CUL4_ARATH (13-738): 0: 727: 32.56
+	Hs
		256749 CAND2_HUMAN (2-1219): 0: 737: 38.14		CUL3_HUMAN (1-738): 0: 796: 30.09
+	Hs
		1041074 CAND1_HUMAN (2-1219): 0: 796: 42.73		CUL1_HUMAN (4-738): 0: 729: 30.41
+	Mm
		1169688 CAND1_MOUSE (2-1219): 0: 795: 42.41		CUL1_MOUSE (4-738): 0: 729: 30.41
+	Dm
		1213848 CAND1_DROME (4-1219): 0: 721: 38.83		Q8IP45_DROME (2-738): 0: 768: 30.93
+	Hs
		1041383 CAND1_HUMAN (2-1219): 0: 796: 42.73		CUL2_HUMAN (1-738): 0: 688: 27.05
+	Mm
		1169706 CAND2_MOUSE (3-1219): 0: 755: 38.12		CUL1_MOUSE (4-738): 0: 729: 30.41
+	Hs
		256748 CAND2_HUMAN (2-1219): 0: 737: 38.14		CUL1_HUMAN (4-738): 0: 729: 30.41
+	Dm
		1097204 CAND1_DROME (4-1219): 0: 721: 38.83		CUL1_DROME (3-738): 0: 692: 27.81
+	Hs
		1202033 CAND1_HUMAN (2-1219): 0: 796: 42.73		CUL5_HUMAN (3-738): 0: 615: 24.14
+	Ce
		105747 CAND1_CAEEL (1-1219): 0: 591: 28.73		CUL3_CAEEL (1-738): 0: 707: 25.61
+	Ce
		105745 CAND1_CAEEL (1-1219): 0: 591: 28.73		CUL1_CAEEL (2-738): 0: 670: 27.26
+	Ce
		105746 CAND1_CAEEL (1-1219): 0: 591: 28.73		CUL2_CAEEL (1-738): 0: 638: 24.53
+	Ce
		105749 CAND1_CAEEL (1-1219): 0: 591: 28.73		CUL6_CAEEL (6-738): 0: 619: 26.08
+	Ce
		105748 CAND1_CAEEL (1-1219): 0: 591: 28.73		CUL4_CAEEL (19-738): 0: 572: 26.03
+	Ce
		105750 CAND1_CAEEL (1-1219): 0: 591: 28.73		CUL5_CAEEL (6-738): 0: 570: 23.06
+	Sp
		142920 CAND1_SCHPO (8-1219): 2.41e-112: 382: 18.69		CUL1_SCHPO (3-738): 0: 680: 27.94