HitPredict

Interactor 1: CSN5A (Q8LAZ7)
COP9 signalosome complex subunit 5a (Signalosome subunit 5a) (EC 3.4.-.-) (Jun activation domain-binding homolog 1)
Gene: CSN5A

Interactor 2: CSN6A (Q8W206)
COP9 signalosome complex subunit 6a (AtCSN6a) (Signalosome subunit 6a)
Gene: CSN6A

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	11742986, 12615944, 15486099, 11701877
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CSN5_C~JAB, CSN5_C~MitMem_reg, JAB~JAB, JAB~MitMem_reg
Common GO terms	GO:0000338 - protein deneddylation GO:0005737 - cytoplasm GO:0008180 - COP9 signalosome GO:0008237 - metallopeptidase activity GO:0009585 - red, far-red light phototransduction and 1 others more... GO:0010387 - COP9 signalosome assembly
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 357 At			1 317
+	At
		1091620 CSN5A_ARATH (1-357): 2.09e-139: 401: 100.00		Q1EC57_ARATH (1-317): 1.18e-122: 356: 100.00
+	At
		1227247 CSN5A_ARATH (1-357): 2.09e-139: 401: 100.00		CSN6B_ARATH (1-317): 2.85e-122: 355: 87.38
+	At
		1258863 CSN5B_ARATH (1-356): 1.45e-134: 389: 85.71		CSN6A_ARATH (1-317): 1.18e-122: 356: 100.00
+	At
		1258851 CSN5B_ARATH (1-356): 1.45e-134: 389: 85.71		CSN6B_ARATH (1-317): 2.85e-122: 355: 87.38
+	Dm
		1363294 CSN5_DROME (6-342): 6.46e-129: 373: 63.80		CSN6_DROME (1-307): 8.35e-101: 301: 37.42
+	Hs
		1184934 CSN5_HUMAN (1-338): 6.45e-123: 359: 65.09		CSN6_HUMAN (1-307): 9.13e-106: 313: 37.86
+	Mm
		193510 CSN5_MOUSE (1-338): 4.4e-123: 359: 65.09		CSN6_MOUSE (1-307): 9.6e-105: 310: 37.86
+	Hs
		124919 CSN5_HUMAN (1-338): 6.45e-123: 359: 65.09		EIF3F_HUMAN (1-297): 9.85e-97: 291: 24.00
+	At
		1227264 CSN5A_ARATH (1-357): 2.09e-139: 401: 100.00		EIF3H_ARATH (5-272): 2.16e-44: 156: 10.44
+	Ce
		954223 CSN5_CAEEL (5-354): 7.71e-116: 342: 52.57		CSN6_CAEEL (2-301): 6.01e-65: 212: 23.03
+	Hs
		72127 EIF3H_HUMAN (51-350): 7.18e-84: 260: 16.89		B3KSH1_HUMAN (1-297): 1.09e-96: 292: 24.00
+	Hs
		124674 EIF3H_HUMAN (51-350): 7.18e-84: 260: 16.89		EIF3F_HUMAN (1-297): 9.85e-97: 291: 24.00
+	Dm
		640778 PSDE_DROME (42-312): 2.1e-83: 257: 33.33		PSMD7_DROME (1-312): 4.72e-92: 278: 21.56
+	Hs
		177079 EIF3H_HUMAN (51-350): 7.18e-84: 260: 16.89		Q9BX72_HUMAN (1-296): 8.48e-89: 270: 22.00
+	Hs
		130804 PSDE_HUMAN (49-312): 3.09e-81: 251: 32.98		PSMD7_HUMAN (7-308): 1.83e-89: 272: 21.36
+	An
		1124327 CSN5_EMENI (8-342): 1.28e-108: 322: 51.63		CSN6_EMENI (4-313): 3.81e-45: 159: 26.00
+	Sp
		293443 CSN5_SCHPO (30-336): 3.24e-89: 271: 40.26		CSN5_SCHPO (58-180): 2.55e-28: 112: 17.42
+	Zm
		76065 K7TNP5_MAIZE (39-349): 4.22e-82: 255: 16.56		B4FLQ8_MAIZE (2-161): 4.5e-20: 90.2: 13.69
+	Zm
		76063 B4FLQ8_MAIZE (37-312): 2.18e-82: 254: 29.10		B4FLQ8_MAIZE (2-161): 4.5e-20: 90.2: 13.69