HitPredict

Interactor 1: CKB21 (Q8LF80)
Cyclin-dependent kinase B2-1 (CDKB2;1) (EC 2.7.11.22) (EC 2.7.11.23)
Gene: CDKB2-1

Interactor 2: CCD41 (Q8LGA1)
Cyclin-D4-1 (G1/S-specific cyclin-D4-1) (CycD4;1)
Gene: CYCD4-1

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	12857813, 20407024
Identification Methods	pull down, two hybrid, protein complementation assay, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 313 At			1 308
+	At
		1104370 CKB21_ARATH (1-313): 1.22e-145: 414: 100.00		CCA23_ARATH (17-308): 5.59e-91: 279: 19.52
+	Hs
		538471 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		CCNB1_HUMAN (2-308): 7.01e-88: 271: 13.10
+	Hs
		625350 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		CCNA1_HUMAN (19-306): 6.4e-85: 264: 21.11
+	At
		1059420 CKB21_ARATH (1-313): 1.22e-145: 414: 100.00		CCA22_ARATH (7-308): 3.36e-86: 266: 18.54
+	Hs
		303829 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		CCNB2_HUMAN (2-308): 2.22e-84: 261: 17.36
+	At
		790183 CKB21_ARATH (1-313): 1.22e-145: 414: 100.00		CCD21_ARATH (32-301): 8.34e-87: 265: 47.41
+	Hs
		590125 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		CCNA2_HUMAN (3-305): 3.18e-79: 248: 19.34
+	At
		790168 CKB21_ARATH (1-313): 1.22e-145: 414: 100.00		CCD11_ARATH (5-272): 5.8e-82: 252: 37.27
+	At
		790210 CKB21_ARATH (1-313): 1.22e-145: 414: 100.00		CCD31_ARATH (9-270): 2.17e-78: 245: 34.44
+	At
		672519 CKB21_ARATH (1-313): 1.22e-145: 414: 100.00		CCB11_ARATH (18-305): 8.52e-77: 242: 18.34
+	Rn
		981205 Q6P751_RAT (11-310): 8.42e-148: 418: 53.49		CCND2_RAT (8-280): 4.29e-73: 228: 28.11
+	Hs
		624539 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		CCNE1_HUMAN (6-271): 8.26e-70: 224: 22.58
+	At
		1013004 CKB21_ARATH (1-313): 1.22e-145: 414: 100.00		CCD42_ARATH (8-286): 6.61e-73: 228: 69.53
+	Hs
		625155 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		CCND2_HUMAN (8-280): 4.98e-71: 223: 27.40
+	Rn
		70081 Q6P751_RAT (11-310): 8.42e-148: 418: 53.49		B1WC54_RAT (6-244): 1.42e-60: 200: 21.57
+	Hs
		625156 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		CCND3_HUMAN (8-284): 1.32e-59: 194: 22.60
+	At
		1103321 CKB21_ARATH (1-313): 1.22e-145: 414: 100.00		CCD51_ARATH (1-268): 5.74e-61: 198: 28.72
+	Hs
		331629 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		CCNE2_HUMAN (33-283): 1.26e-55: 186: 25.10
+	Hs
		622358 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		CCND1_HUMAN (22-266): 2.34e-55: 183: 27.64
+	Hs
		625523 CDK2_HUMAN (11-310): 3.47e-148: 419: 53.82		Q8WUE3_HUMAN (33-283): 1.35e-54: 183: 25.10