HitPredict

Interactor 1: MEN1 (O00255)
Menin
Gene: MEN1

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0035097 - histone methyltransferase complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 610 Hs			1 4911
+	Hs
		122981 MEN1_HUMAN (1-610): 0: 1181: 100.00		NSD3_HUMAN (1-668): 2.87e-64: 246: 13.52
+	Hs
		122367 MEN1_HUMAN (1-610): 0: 1181: 100.00		SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73
+	Hs
		122764 MEN1_HUMAN (1-610): 0: 1181: 100.00		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		122682 MEN1_HUMAN (1-610): 0: 1181: 100.00		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		122710 MEN1_HUMAN (1-610): 0: 1181: 100.00		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		123099 MEN1_HUMAN (1-610): 0: 1181: 100.00		SET1B_HUMAN (4778-4911): 3.56e-24: 115: 51.11
+	Hs
		123091 MEN1_HUMAN (1-610): 0: 1181: 100.00		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		122360 MEN1_HUMAN (1-610): 0: 1181: 100.00		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82