HitPredict

Interactor 1: SPART (Q8N0X7)
Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)
Gene: SPART

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	28514442, 19765186, 19580544, 19307600, 31340145, 33961781
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 666 Hs			1 922
+	Hs
		1229716 SPART_HUMAN (1-666): 0: 631: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125574 SPART_HUMAN (1-666): 0: 631: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		875071 TERA_HUMAN (172-509): 3.81e-74: 256: 10.53		HUWE1_HUMAN (130-921): 1.4e-172: 559: 24.48
+	Hs
		1229727 SPART_HUMAN (1-666): 0: 631: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		1229725 SPART_HUMAN (1-666): 0: 631: 100.00		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Sc
		636723 CDC48_YEAST (94-430): 4.48e-72: 251: 11.83		TOM1_YEAST (439-921): 2.08e-156: 512: 31.81
+	Hs
		1229731 SPART_HUMAN (1-666): 0: 631: 100.00		HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11
+	Hs
		1350491 SPAST_HUMAN (9-458): 7.59e-112: 351: 16.94		HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11
+	Sc
		636637 CDC48_YEAST (94-430): 4.48e-72: 251: 11.83		RSP5_YEAST (16-424): 6.88e-44: 173: 20.05
+	Hs
		875337 TERA_HUMAN (172-509): 3.81e-74: 256: 10.53		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82