HitPredict

Interactor 1: SPART (Q8N0X7)
Spartin (Spastic paraplegia 20 protein) (Trans-activated by hepatitis C virus core protein 1)
Gene: SPART

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	0.60	0.595

Property	Details
Experiments	19307600, 15231748
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030514 - negative regulation of BMP signaling pathway
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 666 Hs			1 748
+	Hs
		1229727 SPART_HUMAN (1-666): 0: 631: 100.00		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Hs
		875337 TERA_HUMAN (172-509): 3.81e-74: 256: 10.53		SMUF1_HUMAN (1-748): 0: 748: 70.44
+	Sc
		636637 CDC48_YEAST (94-430): 4.48e-72: 251: 11.83		RSP5_YEAST (11-748): 0: 638: 34.33
+	Hs
		875071 TERA_HUMAN (172-509): 3.81e-74: 256: 10.53		HUWE1_HUMAN (114-747): 0: 589: 31.46
+	Sc
		636723 CDC48_YEAST (94-430): 4.48e-72: 251: 11.83		TOM1_YEAST (325-747): 1.36e-156: 505: 40.47
+	Hs
		125574 SPART_HUMAN (1-666): 0: 631: 100.00		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		1229716 SPART_HUMAN (1-666): 0: 631: 100.00		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		1229721 SPART_HUMAN (1-666): 0: 631: 100.00		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47
+	Hs
		1229731 SPART_HUMAN (1-666): 0: 631: 100.00		HECW2_HUMAN (19-281): 8.01e-17: 87.5: 14.80
+	Hs
		1350491 SPAST_HUMAN (9-458): 7.59e-112: 351: 16.94		HECW2_HUMAN (19-281): 8.01e-17: 87.5: 14.80