HitPredict

Interactor 1: DOCK4 (Q8N1I0)
Dedicator of cytokinesis protein 4
Gene: DOCK4

Interactor 2: ELMO2 (Q96JJ3)
Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A)
Gene: ELMO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	32296183, 32203420, 33961781
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	DOCK_N~PH_12
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0017124 - SH3 domain binding GO:0030971 - receptor tyrosine kinase binding GO:0060326 - cell chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1966 Hs			1 720
+	Hs
		1061751 Q149N5_HUMAN (1-1966): 0: 2043: 97.61		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		1230987 DOCK4_HUMAN (1-1966): 0: 2081: 100.00		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Hs
		1230990 DOCK4_HUMAN (1-1966): 0: 2081: 100.00		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Hs
		1224227 DOCK3_HUMAN (1-1963): 0: 1836: 53.65		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		1267934 DOCK2_HUMAN (2-1771): 0: 1830: 35.49		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Mm
		1206593 DOCK1_MOUSE (2-1795): 0: 1822: 36.38		ELMO2_MOUSE (1-720): 0: 1042: 97.13
+	Hs
		1050489 DOCK1_HUMAN (2-1792): 0: 1798: 36.67		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		1224220 DOCK3_HUMAN (1-1963): 0: 1836: 53.65		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Hs
		1267020 DOCK2_HUMAN (2-1771): 0: 1830: 35.49		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Mm
		1207130 DOCK2_MOUSE (2-1771): 0: 1827: 35.73		ELMO1_MOUSE (1-718): 0: 1010: 75.34
+	Mm
		1207128 DOCK1_MOUSE (2-1795): 0: 1822: 36.38		ELMO1_MOUSE (1-718): 0: 1010: 75.34
+	Hs
		1050484 DOCK1_HUMAN (2-1792): 0: 1798: 36.67		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Hs
		1295265 DOCK5_HUMAN (2-1790): 0: 1744: 34.82		ELMO2_HUMAN (1-720): 0: 1053: 100.00
+	Hs
		1224225 DOCK3_HUMAN (1-1963): 0: 1836: 53.65		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Mm
		1207312 DOCK1_MOUSE (2-1795): 0: 1822: 36.38		ELMO3_MOUSE (1-719): 0: 944: 51.11
+	Hs
		1267024 DOCK5_HUMAN (2-1790): 0: 1744: 34.82		ELMO1_HUMAN (1-718): 0: 1012: 75.48
+	Hs
		1050487 DOCK1_HUMAN (2-1792): 0: 1798: 36.67		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Hs
		1285559 DOCK5_HUMAN (2-1790): 0: 1744: 34.82		ELMO3_HUMAN (1-718): 0: 944: 50.49
+	Dm
		1362934 Q9VCH4_DROME (5-1856): 0: 1618: 29.05		Q9VKB2_DROME (5-718): 0: 839: 44.60
+	Dm
		81396 B7Z0R2_DROME (1-1746): 0: 1581: 38.15		Q9VKB2_DROME (5-718): 0: 839: 44.60