HitPredict

Interactor 1: LTBP4 (Q8N2S1)
Latent-transforming growth factor beta-binding protein 4 (LTBP-4)
Gene: LTBP4

Interactor 2: VWCE (Q96DN2)
von Willebrand factor C and EGF domain-containing protein (HBV X protein up-regulated gene 11 protein) (HBxAg up-regulated gene 11 protein)
Gene: VWCE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1624 Hs			1 955
+	Hs
		980445 LTBP4_HUMAN (1-1624): 0: 640: 100.00		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		1231807 LTBP4_HUMAN (1-1624): 0: 640: 100.00		FBLN5_HUMAN (61-281): 2.58e-37: 148: 30.21
+	Hs
		612884 LTBP4_HUMAN (1-1624): 0: 640: 100.00		FBLN1_HUMAN (149-534): 1.88e-20: 99.1: 18.80
+	Hs
		1231800 LTBP4_HUMAN (1-1624): 0: 640: 100.00		NELL2_HUMAN (386-747): 4.84e-11: 68.7: 19.18
+	Hs
		1231791 LTBP4_HUMAN (1-1624): 0: 640: 100.00		NELL1_HUMAN (386-746): 8.55e-11: 67.9: 19.77
+	Hs
		724347 LTBP4_HUMAN (1-1624): 0: 640: 100.00		FBN1_HUMAN (125-262): 3.99e-09: 63.2: 37.67
+	Hs
		980576 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		NOTC2_HUMAN (224-849): 3.36e-38: 157: 12.27
+	Hs
		1357251 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		JAG2_HUMAN (209-851): 1.57e-28: 125: 10.62
+	Hs
		1357250 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		NOTC3_HUMAN (1-511): 7.1e-24: 111: 14.21
+	Hs
		1059044 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		LTBP1_HUMAN (141-573): 5e-21: 101: 20.00
+	Hs
		612912 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		FBLN1_HUMAN (149-534): 1.88e-20: 99.1: 18.80
+	Hs
		944134 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		JAG1_HUMAN (472-832): 1.91e-17: 90.2: 10.33
+	Hs
		804372 NOTC3_HUMAN (396-1624): 7.04e-107: 380: 16.83		NOTC1_HUMAN (6-391): 9.43e-14: 78.2: 11.19
+	Hs
		980413 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		NPNT_HUMAN (43-279): 6.48e-55: 202: 30.49
+	Hs
		980375 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		LTBP1_HUMAN (141-573): 5e-21: 101: 20.00
+	Hs
		612843 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		FBLN1_HUMAN (149-534): 1.88e-20: 99.1: 18.80
+	Hs
		944119 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		JAG1_HUMAN (472-832): 1.91e-17: 90.2: 10.33
+	Hs
		980450 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		BMPER_HUMAN (372-564): 7.24e-16: 84.5: 25.00
+	Hs
		724367 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		FBN2_HUMAN (3-483): 4.74e-15: 82.4: 12.34
+	Hs
		804213 NOTC2_HUMAN (16-812): 8.31e-50: 197: 14.64		NOTC1_HUMAN (6-391): 9.43e-14: 78.2: 11.19