HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: DCAF7 (P61962)
DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)
Gene: DCAF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	27705803
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016604 - nuclear body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 342
+	Hs
		315993 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00
+	Hs
		1059181 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		SNR40_HUMAN (116-342): 3.78e-43: 154: 13.66
+	Hs
		327833 CBX7_HUMAN (1-250): 1.04e-38: 144: 30.71		DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00
+	Hs
		997961 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98
+	Hs
		903028 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		DCAF7_HUMAN (1-342): 5.45e-87: 267: 100.00
+	Hs
		997703 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98
+	Mm
		1141931 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		RBBP4_MOUSE (10-342): 2.39e-68: 221: 13.98
+	Hs
		800395 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		RBBP7_HUMAN (10-342): 1.27e-68: 222: 14.51
+	Hs
		800356 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98
+	At
		186933 LHP1_ARATH (4-292): 3.94e-47: 172: 17.51		MSI1_ARATH (17-342): 3.99e-58: 195: 15.00
+	Hs
		949761 CBX1_HUMAN (17-163): 1.89e-39: 144: 21.05		RBBP4_HUMAN (10-342): 2.39e-68: 221: 13.98
+	Mm
		222466 SUV91_MOUSE (4-154): 5.07e-34: 135: 22.44		RBBP7_MOUSE (10-342): 1.03e-68: 222: 14.51
+	Mm
		222465 SUV91_MOUSE (4-154): 5.07e-34: 135: 22.44		RBBP4_MOUSE (10-342): 2.39e-68: 221: 13.98
+	Hs
		1288395 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		SNR40_HUMAN (116-342): 3.78e-43: 154: 13.66
+	Hs
		1288317 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		SNR40_HUMAN (116-342): 3.78e-43: 154: 13.66
+	Hs
		903191 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85
+	Hs
		903125 CBX1_HUMAN (17-163): 1.89e-39: 144: 21.05		WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85
+	Hs
		800458 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		DAW1_HUMAN (216-342): 1.48e-25: 107: 14.96
+	Hs
		903532 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		WDR5_HUMAN (208-342): 8.98e-29: 115: 11.85
+	Hs
		1335779 CBX8_HUMAN (1-259): 7.16e-33: 131: 28.22		NLE1_HUMAN (249-341): 1.44e-21: 97.2: 15.05