HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	36931259, 21282530
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043066 - negative regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 560 Hs			1 245
+	Hs
		123219 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		123184 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		123189 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		123218 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		123242 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		123190 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Mm
		926802 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Mm
		935508 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		1433F_MOUSE (2-240): 1.16e-107: 312: 74.07