HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12829790
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Chromo~PHD
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 3969
+	Hs
		975237 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		123140 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Hs
		1027329 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		1080489 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Mm
		936655 Q9DCC5_MOUSE (9-163): 8.8e-44: 155: 21.94		EZH1_MOUSE (3468-3951): 9.84e-108: 366: 18.49
+	Mm
		1142295 Q9DCC5_MOUSE (9-163): 8.8e-44: 155: 21.94		EZH2_MOUSE (3450-3951): 3.64e-105: 358: 18.54
+	Mm
		1142272 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		EZH2_MOUSE (3450-3951): 3.64e-105: 358: 18.54
+	Mm
		613035 CBX3_MOUSE (9-163): 1.02e-43: 155: 21.29		SUV92_MOUSE (3497-3969): 3.31e-92: 311: 16.90
+	Hs
		1027242 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61
+	Hs
		203674 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Mm
		222460 CBX3_MOUSE (9-163): 1.02e-43: 155: 21.29		SUV91_MOUSE (3630-3968): 3.28e-83: 283: 18.97
+	Mm
		222468 Q9DCC5_MOUSE (9-163): 8.8e-44: 155: 21.94		SUV91_MOUSE (3630-3968): 3.28e-83: 283: 18.97
+	Hs
		1027262 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SUV92_HUMAN (3577-3969): 7.13e-82: 278: 18.97
+	Hs
		203823 V9HWG0_HUMAN (11-171): 7.04e-41: 148: 19.88		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Mm
		222467 CBX5_MOUSE (11-169): 3.2e-41: 149: 20.71		SUV91_MOUSE (3630-3968): 3.28e-83: 283: 18.97
+	Hs
		331801 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		1027243 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		165670 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		1317731 V9HWG0_HUMAN (11-171): 7.04e-41: 148: 19.88		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		1027214 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18