HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 726
+	Hs
		123181 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		1067203 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		1027010 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		800386 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		123146 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		631418 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		631371 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		631399 CBX1_HUMAN (17-163): 1.89e-39: 144: 21.05		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		876716 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		BRPF1_HUMAN (20-274): 6.8e-26: 116: 14.94
+	Hs
		244836 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		1262805 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		PHIP_HUMAN (5-708): 5.37e-19: 94.5: 10.37
+	Hs
		1027327 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21
+	Hs
		243752 CBX6_HUMAN (1-419): 4.68e-61: 209: 24.19		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		998641 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		800357 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		1027324 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRPF3_HUMAN (37-484): 7.42e-31: 132: 14.82
+	Hs
		244377 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		1027151 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		PHIP_HUMAN (5-708): 5.37e-19: 94.5: 10.37
+	Hs
		244073 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		244280 CBX1_HUMAN (17-163): 1.89e-39: 144: 21.05		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56