HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	27705803, 27505670, 24981860
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 259
+	Hs
		123193 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		123194 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		123257 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Mm
		223225 CBX4_MOUSE (1-560): 5.82e-156: 459: 88.43		PCGF2_MOUSE (30-255): 2.33e-56: 185: 35.98
+	Hs
		123317 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		123273 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		PCGF5_HUMAN (30-257): 3.38e-44: 151: 29.41
+	Hs
		123308 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		123174 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		RO52_HUMAN (32-226): 9.58e-36: 134: 18.61
+	Hs
		123243 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Mm
		223231 CBX4_MOUSE (1-560): 5.82e-156: 459: 88.43		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Mm
		1164651 Q6TKP2_MOUSE (1-506): 1.06e-127: 390: 23.50		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Dr
		1186372 Q804D1_DANRE (1-558): 1.48e-100: 314: 40.50		BMI1B_DANRE (30-255): 6.8e-65: 207: 36.44
+	Dr
		1193374 Q804D1_DANRE (1-558): 1.48e-100: 314: 40.50		BMI1A_DANRE (30-255): 2.14e-61: 197: 35.59
+	Hs
		718131 MPP8_HUMAN (6-431): 5.25e-87: 289: 13.72		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Mm
		639466 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		BMI1_MOUSE (30-255): 1.56e-62: 200: 35.59
+	Mm
		620782 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		PCGF2_MOUSE (30-255): 2.33e-56: 185: 35.98
+	Hs
		717831 CBX2_HUMAN (2-559): 1.19e-82: 269: 23.54		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Dr
		1193367 Q804D1_DANRE (1-558): 1.48e-100: 314: 40.50		RING2_DANRE (24-259): 5.59e-38: 137: 16.56
+	Mm
		675501 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Mm
		193405 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		RING1_MOUSE (24-155): 5.39e-33: 125: 20.59