HitPredict

Interactor 1: RYBP (Q8N488)
RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)
Gene: RYBP

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 24457600, 26496610, 27705803, 32296183, 20696397, 35933409, 22325352, 26186194, 28514442, 30040487, 24981860, 33961781, 34316702, 16943429, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, x-ray crystallography, pull down, ion exchange chromatography, cosedimentation in solution, nuclear magnetic resonance, surface plasmon resonance, anti tag coimmunoprecipitation, tandem affinity purification and 4 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains RAWUL~YAF2_RYBP
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006338 - chromatin remodeling
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 228
Hs

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Last updated: 15 Jul 2024