HitPredict

Interactor 1: CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Gene: CBX4

Interactor 2: HELLS (Q9NRZ9)
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
Gene: HELLS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Chromo~SNF2-rel_dom
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 560 Hs			1 838
+	Hs
		123332 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		CHD7_HUMAN (31-836): 0: 657: 27.28
+	Hs
		123245 CBX4_HUMAN (1-560): 7.58e-163: 477: 100.00		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Mm
		675497 CBX2_MOUSE (2-559): 8.06e-91: 290: 22.85		HELLS_MOUSE (17-838): 0: 724: 91.24
+	Hs
		1027286 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		HELLS_HUMAN (1-838): 0: 763: 100.00
+	Hs
		847118 CDYL_HUMAN (2-288): 4.47e-50: 183: 16.35		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		1027300 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD7_HUMAN (31-836): 0: 657: 27.28
+	Hs
		1018451 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		800360 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		1027277 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD8_HUMAN (2-836): 0: 635: 26.71
+	Hs
		846954 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		1027001 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Mm
		1161080 Q9DCC5_MOUSE (9-163): 8.8e-44: 155: 21.94		CHD4_MOUSE (51-828): 0: 629: 25.39
+	Hs
		1027145 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD5_HUMAN (50-835): 0: 627: 24.83
+	Hs
		800320 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		1027026 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD9_HUMAN (3-836): 0: 619: 26.49
+	Hs
		229384 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		658667 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SMCA1_HUMAN (104-833): 0: 596: 31.06
+	Hs
		800319 CBX5_HUMAN (11-171): 7.04e-41: 148: 19.88		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		1027099 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		CHD1L_HUMAN (218-755): 1.8e-105: 347: 40.30
+	Hs
		1027257 CBX3_HUMAN (9-163): 8.8e-44: 155: 21.94		SMRCD_HUMAN (206-744): 1.53e-92: 315: 37.59