HitPredict

Interactor 1: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19953087
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1332 Hs			1 975
+	Mm
		949373 TNIK_MOUSE (1-1332): 0: 1112: 62.60		NED4L_MOUSE (17-975): 0: 1014: 98.02
+	Mm
		93268 TNIK_MOUSE (1-1332): 0: 1112: 62.60		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Mm
		808345 TNIK_MOUSE (1-1332): 0: 1112: 62.60		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Hs
		808315 TNIK_HUMAN (1-1332): 0: 1098: 60.83		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Mm
		949337 TNIK_MOUSE (1-1332): 0: 1112: 62.60		HUWE1_MOUSE (372-973): 2.88e-171: 557: 33.66
+	Hs
		1183099 MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		1336112 TNIK_HUMAN (1-1332): 0: 1098: 60.83		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		1027416 STK3_HUMAN (3-507): 3.96e-120: 384: 30.12		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808172 MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808229 MARK4_HUMAN (16-739): 9.59e-118: 387: 17.15		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808110 STK4_HUMAN (5-469): 5.1e-119: 381: 32.99		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		131554 STK25_HUMAN (20-413): 1.71e-119: 380: 37.37		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808341 STK24_HUMAN (20-443): 5.39e-117: 374: 34.98		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808304 STK26_HUMAN (16-413): 5.32e-114: 365: 37.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808337 M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		1023072 STK4_HUMAN (5-469): 5.1e-119: 381: 32.99		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		1183127 MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		972468 M3K10_HUMAN (21-845): 1.48e-113: 381: 19.26		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		1336133 M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71