HitPredict

Interactor 1: TAB3 (Q8N5C8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
Gene: TAB3

Interactor 2: TRIM5 (Q9C035)
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)
Gene: TRIM5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21512573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 712 Hs			1 493
+	Hs
		536926 TAB3_HUMAN (1-712): 8.19e-99: 321: 100.00		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21
+	Mm
		548982 TAB3_MOUSE (1-712): 2.53e-96: 315: 94.69		TR30A_MOUSE (1-493): 6.2e-115: 349: 44.49
+	Hs
		135034 TAB3_HUMAN (1-712): 8.19e-99: 321: 100.00		TRI38_HUMAN (1-491): 1.02e-110: 337: 31.65
+	Hs
		1318714 TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53		TRIM5_HUMAN (1-493): 3.88e-147: 432: 100.00
+	Hs
		1223392 TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53		TRI22_HUMAN (1-493): 8.67e-130: 387: 50.98
+	Hs
		537101 TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21
+	Mm
		548987 TAB2_MOUSE (1-711): 4.55e-45: 173: 28.09		TR30A_MOUSE (1-493): 6.2e-115: 349: 44.49
+	Hs
		135043 TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53		TRI38_HUMAN (1-491): 1.02e-110: 337: 31.65
+	Hs
		537122 MAGL2_HUMAN (48-676): 3.64e-10: 65.6: 9.89		TRI27_HUMAN (1-492): 5.51e-121: 365: 29.21