HitPredict

Interactor 1: TAB3 (Q8N5C8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
Gene: TAB3

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	23986494, 15327770
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0042742 - defense response to bacterium GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0070530 - K63-linked polyubiquitin modification-dependent protein binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 712 Hs			1 419
+	Hs
		1348539 TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		554389 MUC1_HUMAN (54-680): 4.91e-23: 107: 9.24		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		124140 SPT5H_HUMAN (58-209): 8.32e-09: 61.3: 13.64		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		846896 SMCA2_HUMAN (176-599): 1.02e-36: 150: 13.59		MYO5B_HUMAN (64-394): 2.99e-18: 89.7: 16.95
+	Hs
		203228 SYNJ1_HUMAN (252-685): 6.15e-21: 100: 11.19		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		867114 SC24C_HUMAN (210-493): 5.8e-12: 71.3: 13.44		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		259640 SMCA2_HUMAN (176-599): 1.02e-36: 150: 13.59		LIPA2_HUMAN (31-337): 5.02e-10: 63.9: 15.53
+	Hs
		302310 SC31A_HUMAN (220-598): 4.01e-10: 65.5: 13.19		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		1264783 TITIN_HUMAN (134-417): 2.57e-09: 63.2: 9.72		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		724893 MICA3_HUMAN (61-685): 7.87e-31: 132: 9.58		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		1186077 MICA3_HUMAN (61-685): 7.87e-31: 132: 9.58		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		551790 TITIN_HUMAN (134-417): 2.57e-09: 63.2: 9.72		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Dm
		1213447 Q9VLS7_DROME (55-541): 2.19e-09: 63.3: 9.25		Q8INC1_DROME (48-381): 2e-09: 61.9: 15.83