HitPredict

Interactor 1: ARRD1 (Q8N5I2)
Arrestin domain-containing protein 1 (Alpha-arrestin 1)
Gene: ARRDC1

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	26186194, 28514442, 33961781, 38270169
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Hs			1 975
+	Hs
		1252808 ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		1234607 ARRD1_HUMAN (1-433): 5.38e-131: 386: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Dm
		115614 Q9VI00_DROME (5-389): 3.03e-102: 312: 19.62		M9PFK2_DROME (6-975): 0: 846: 45.79
+	Hs
		1234600 ARRD1_HUMAN (1-433): 5.38e-131: 386: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Dm
		1367624 Q9VI00_DROME (5-389): 3.03e-102: 312: 19.62		NEDD4_DROME (6-975): 0: 845: 46.15
+	Hs
		808187 ARRD1_HUMAN (1-433): 5.38e-131: 386: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125580 ARRD1_HUMAN (1-433): 5.38e-131: 386: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		1252814 ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		1252807 ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Dm
		1367634 Q9VI00_DROME (5-389): 3.03e-102: 312: 19.62		SUDX_DROME (20-971): 0: 747: 32.47
+	Hs
		125595 ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125633 ARRD3_HUMAN (1-373): 1.85e-94: 292: 20.81		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Dm
		89897 Q9I7L0_DROME (6-386): 6.32e-105: 319: 22.52		D5SHR3_DROME (554-972): 0: 535: 44.58
+	Dm
		1337204 Q9I7L0_DROME (6-386): 6.32e-105: 319: 22.52		Q9W325_DROME (554-972): 4.64e-180: 531: 44.58
+	Hs
		1192131 ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Dm
		89904 Q9VI00_DROME (5-389): 3.03e-102: 312: 19.62		D5SHR3_DROME (554-972): 0: 535: 44.58
+	Dm
		1367630 Q9VI00_DROME (5-389): 3.03e-102: 312: 19.62		Q9W325_DROME (554-972): 4.64e-180: 531: 44.58
+	Hs
		1234609 ARRD1_HUMAN (1-433): 5.38e-131: 386: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		1234613 ARRD1_HUMAN (1-433): 5.38e-131: 386: 100.00		HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84
+	Hs
		1252817 ARRD2_HUMAN (2-371): 6.72e-95: 293: 22.36		HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84