HitPredict

Interactor 1: RNF10 (Q8N5U6)
E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10)
Gene: RNF10

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	33961781, 19549727
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 811 Hs			1 147
+	Hs
		849368 RNF10_HUMAN (1-811): 0: 1013: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919785 RNF10_HUMAN (1-811): 0: 1013: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895845 RNF10_HUMAN (1-811): 0: 1013: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1235230 RNF10_HUMAN (1-811): 0: 1013: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1235226 RNF10_HUMAN (1-811): 0: 1013: 100.00		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851843 RNF10_HUMAN (1-811): 0: 1013: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Sc
		549836 MAG2_YEAST (3-695): 6.81e-156: 472: 20.19		UBC4_YEAST (3-147): 9.94e-80: 233: 80.69
+	Hs
		749252 BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		749339 BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		749301 BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		749782 BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		749752 BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		749256 BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Dm
		639398 Q8IR26_DROME (194-307): 2.55e-39: 149: 26.09		UBCD1_DROME (1-147): 4.66e-82: 239: 92.52
+	Dm
		639411 Q9VXP1_DROME (194-307): 4.34e-39: 148: 26.09		UBCD1_DROME (1-147): 4.66e-82: 239: 92.52
+	Hs
		749303 BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Dm
		854562 Q8IR26_DROME (194-307): 2.55e-39: 149: 26.09		UBCD2_DROME (4-146): 7.36e-75: 224: 65.73
+	Dm
		854578 Q9VXP1_DROME (194-307): 4.34e-39: 148: 26.09		UBCD2_DROME (4-146): 7.36e-75: 224: 65.73
+	Dm
		1215059 Q8IR26_DROME (194-307): 2.55e-39: 149: 26.09		Q9I7T6_DROME (1-146): 3.53e-50: 165: 52.74
+	Dm
		1337333 Q9VXP1_DROME (194-307): 4.34e-39: 148: 26.09		Q9I7T6_DROME (1-146): 3.53e-50: 165: 52.74