HitPredict

Interactor 1: SIR6 (Q8N6T7)
NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)
Gene: SIRT6

Interactor 2: FYCO1 (Q9BQS8)
FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)
Gene: FYCO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 34244565
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 1478
+	Hs
		522628 SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00		MYH7_HUMAN (1-631): 4.24e-24: 113: 8.32
+	Hs
		551779 SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00		DESP_HUMAN (232-1121): 6.82e-14: 79.7: 22.05
+	Hs
		72466 B4DDV3_HUMAN (73-355): 1.52e-119: 348: 100.00		MYH7_HUMAN (1-631): 4.24e-24: 113: 8.32
+	Hs
		725037 SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61		MYH9_HUMAN (1-843): 7.74e-35: 148: 11.32
+	Hs
		725253 SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61		MYH10_HUMAN (1-594): 9.36e-27: 121: 12.67
+	Hs
		149356 SIR5_HUMAN (22-264): 6.55e-77: 240: 19.20		CTRO_HUMAN (195-970): 2.82e-38: 159: 15.44
+	Hs
		551850 SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61		DESP_HUMAN (232-1121): 6.82e-14: 79.7: 22.05
+	Hs
		1068679 SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61		PLEC_HUMAN (385-1169): 2.58e-09: 64.7: 22.38