HitPredict

Interactor 1: SIR6 (Q8N6T7)
NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)
Gene: SIRT6

Interactor 2: CELR2 (Q9HCU4)
Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3)
Gene: CELSR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 2923
+	Hs
		1236541 SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00		CELR1_HUMAN (2-930): 1.04e-158: 556: 23.83
+	Hs
		1236542 SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00		CELR3_HUMAN (3-601): 1.13e-115: 416: 21.99
+	Hs
		1167028 SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00		FAT4_HUMAN (1867-2037): 5.61e-14: 81.1: 13.26
+	Hs
		1236390 SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00		FAT3_HUMAN (1479-1625): 3.21e-13: 78.4: 20.40
+	Hs
		1054995 SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00		FAT1_HUMAN (1306-1492): 3.57e-11: 71.8: 9.79