HitPredict

Interactor 1: SIR6 (Q8N6T7)
NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)
Gene: SIRT6

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24169447, 34244565
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 456
+	Hs
		1236582 SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1345682 SIR3_HUMAN (33-287): 6.34e-90: 276: 27.92		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Sc
		864140 HST2_YEAST (31-272): 3.57e-76: 240: 23.59		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		864156 HST2_YEAST (31-272): 3.57e-76: 240: 23.59		RUVB2_YEAST (5-455): 0: 627: 41.72