Interactor 1: CIKS (Q8N7N6)
E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)
Gene: Traf3ip2

Interactor 2: IKKE (Q9R0T8)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: Ikbke

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 0.60 0.602

The method score is based on:

Property Details
Experiments 22851696, 21822257
Identification Methods enzymatic study, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0006955 - immune response
GO:0010467 - gene expression
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0048255 - mRNA stabilization
and 1 others

more...

Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 555
Mm

1 717
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024