HitPredict

Interactor 1: SPT5H (O00267)
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)
Gene: SUPT5H

Interactor 2: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	28242625, 16169070
Identification Methods	affinity chromatography technology, two hybrid pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding GO:0046982 - protein heterodimerization activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1087 Hs			1 143
+	Hs
		123831 SPT5H_HUMAN (1-1087): 0: 1061: 100.00		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70
+	Sc
		392070 SPT5_YEAST (5-944): 0: 594: 23.73		H2A1_YEAST (16-142): 1.37e-53: 166: 75.59
+	Sc
		392326 SPT5_YEAST (5-944): 0: 594: 23.73		H2A2_YEAST (16-124): 4.61e-53: 165: 82.57
+	Mm
		101453 F8VPR5_MOUSE (649-968): 4.56e-28: 125: 17.15		H2A3_MOUSE (1-129): 5.88e-66: 197: 91.47
+	Hs
		554260 MUC1_HUMAN (746-971): 1.34e-11: 71: 16.30		H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00
+	Hs
		391610 SC24C_HUMAN (794-1057): 2.47e-15: 83.4: 14.88		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70
+	Hs
		391802 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70
+	Hs
		391823 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70