HitPredict

Interactor 1: SPT5H (O00267)
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)
Gene: SUPT5H

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29395067, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1087 Hs			1 551
+	Hs
		124010 SPT5H_HUMAN (1-1087): 0: 1061: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		124074 SPT5H_HUMAN (1-1087): 0: 1061: 100.00		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Sc
		376664 SPT5_YEAST (5-944): 0: 594: 23.73		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Hs
		1084554 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Dm
		375643 RPB1_DROME (765-1072): 8.42e-11: 68.8: 12.35		BRM_DROME (249-551): 1.19e-45: 175: 20.72
+	Hs
		846837 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		847041 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		302269 SC24C_HUMAN (794-1057): 2.47e-15: 83.4: 14.88		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		516595 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		867103 SC24C_HUMAN (794-1057): 2.47e-15: 83.4: 14.88		TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18
+	Dm
		113976 M9PB30_DROME (623-1074): 3.87e-11: 69.9: 10.12		M9PB30_DROME (190-412): 1.36e-12: 73: 16.67
+	Mm
		1351630 PCLO_MOUSE (622-1063): 7.05e-09: 62.6: 11.82		PCLO_MOUSE (195-468): 6.01e-14: 77.6: 11.31
+	Hs
		297843 SC31A_HUMAN (795-1060): 7.42e-11: 68.8: 12.20		SC24D_HUMAN (131-353): 2.02e-11: 68.8: 21.49
+	Mm
		1111938 ZMIZ1_MOUSE (631-1000): 2.78e-10: 66.8: 15.37		SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30
+	Mm
		444961 RPB1_MOUSE (802-916): 3.3e-09: 63.3: 20.00		SMCA4_MOUSE (172-423): 2.26e-10: 65.7: 12.30
+	Mm
		444976 RPB1_MOUSE (802-916): 3.3e-09: 63.3: 20.00		DIDO1_MOUSE (151-446): 1.18e-09: 63.3: 17.16