HitPredict

Interactor 1: SPT5H (O00267)
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)
Gene: SUPT5H

Interactor 2: CTR9 (Q6PD62)
RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)
Gene: CTR9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0006368 - transcription elongation by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1087 Hs			1 1173
+	Sc
		650362 SPT5_YEAST (5-944): 0: 594: 23.73		CTR9_YEAST (5-982): 1.96e-57: 218: 19.58
+	Hs
		175053 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		OGT1_HUMAN (10-501): 1.15e-43: 175: 13.19
+	Hs
		175080 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		OGT1_HUMAN (10-501): 1.15e-43: 175: 13.19
+	Hs
		183137 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Hs
		183144 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Hs
		150104 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		UTY_HUMAN (27-263): 5.38e-18: 92.2: 11.47