HitPredict

Interactor 1: TXND5 (Q8NBS9)
Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)
Gene: TXNDC5

Interactor 2: CALR3 (Q96L12)
Calreticulin-3 (Calreticulin-2) (Calsperin)
Gene: CALR3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31056421, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005788 - endoplasmic reticulum lumen GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 432 Hs			1 384
+	Hs
		1055308 PDIA5_HUMAN (50-426): 2.22e-44: 163: 16.24		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		1067796 PDIA6_HUMAN (15-338): 8.51e-39: 147: 18.00		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		531950 PDIA4_HUMAN (16-191): 7.57e-36: 141: 24.29		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		423330 PDIA1_HUMAN (56-432): 1.58e-28: 119: 16.41		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		671897 PDIA3_HUMAN (22-298): 1.27e-20: 95.8: 16.67		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		653597 PDIA6_HUMAN (15-338): 8.51e-39: 147: 18.00		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		531728 PDIA4_HUMAN (16-191): 7.57e-36: 141: 24.29		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653575 PDIA2_HUMAN (329-430): 1.47e-24: 107: 28.85		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Dm
		667040 PDIA6_DROME (15-237): 1.32e-31: 127: 18.40		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Hs
		653491 PDIA3_HUMAN (22-298): 1.27e-20: 95.8: 16.67		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653650 DJC10_HUMAN (92-405): 1.63e-18: 90: 18.13		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	At
		137900 PDI21_ARATH (327-432): 5.9e-28: 115: 32.71		CALR1_ARATH (3-341): 3.11e-144: 417: 38.94
+	Dm
		667013 PDI_DROME (320-431): 6.41e-23: 102: 35.71		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Dm
		667020 Q3YMU0_DROME (47-185): 2e-21: 98.1: 23.08		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Hs
		531729 PDIA4_HUMAN (16-191): 7.57e-36: 141: 24.29		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Dm
		1359553 PDIA6_DROME (15-237): 1.32e-31: 127: 18.40		Q9VAL7_DROME (22-355): 4.6e-120: 362: 26.51
+	Hs
		423150 PDIA1_HUMAN (56-432): 1.58e-28: 119: 16.41		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		654099 PDIA3_HUMAN (22-298): 1.27e-20: 95.8: 16.67		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Rn
		514119 PDIA3_RAT (39-172): 1.26e-20: 95.8: 25.36		CALX_RAT (16-357): 1.96e-122: 367: 26.97
+	Hs
		654519 DJC10_HUMAN (92-405): 1.63e-18: 90: 18.13		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73