HitPredict

Interactor 1: SPT5H (O00267)
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)
Gene: SUPT5H

Interactor 2: RPR1B (Q9NQG5)
Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor)
Gene: RPRD1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26496610, 29395067, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1087 Hs			1 326
+	Hs
		123970 SPT5H_HUMAN (1-1087): 0: 1061: 100.00		RPRD2_HUMAN (9-322): 2.87e-73: 247: 25.00
+	Hs
		123814 SPT5H_HUMAN (1-1087): 0: 1061: 100.00		PCF11_HUMAN (9-227): 5.39e-41: 154: 18.30
+	Hs
		123816 SPT5H_HUMAN (1-1087): 0: 1061: 100.00		SCAF4_HUMAN (8-187): 2.45e-36: 140: 17.46
+	Sc
		650349 SPT5_YEAST (5-944): 0: 594: 23.73		NRD1_YEAST (7-211): 9.77e-29: 118: 12.99
+	Dm
		90672 RPB1_DROME (765-1072): 8.42e-11: 68.8: 12.35		E1JH68_DROME (7-239): 2.13e-40: 150: 14.94