HitPredict

Interactor 1: TAF4 (O00268)
Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135)
Gene: TAF4

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	26527279, 29568061, 34349018
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1085 Hs			1 136
+	Hs
		124224 TAF4_HUMAN (1-1085): 1.72e-83: 296: 100.00		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		124198 TAF4_HUMAN (1-1085): 1.72e-83: 296: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1086248 TAF4B_HUMAN (205-1085): 1.3e-53: 204: 26.30		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		935004 KMT2C_HUMAN (4-867): 7.32e-31: 134: 12.05		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086228 KMT2C_HUMAN (4-867): 7.32e-31: 134: 12.05		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952479 KMT2C_HUMAN (4-867): 7.32e-31: 134: 12.05		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1174600 KMT2C_HUMAN (4-867): 7.32e-31: 134: 12.05		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		934763 MDC1_HUMAN (4-966): 1.09e-29: 130: 11.32		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952338 MDC1_HUMAN (4-966): 1.09e-29: 130: 11.32		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		828275 ANR11_HUMAN (28-979): 9.58e-37: 153: 12.29		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		935440 CABIN_HUMAN (51-436): 7.14e-16: 85.4: 17.12		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952733 CABIN_HUMAN (51-436): 7.14e-16: 85.4: 17.12		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Mm
		101827 F8WI37_MOUSE (212-886): 3e-13: 76.9: 9.62		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		934880 ADNP2_HUMAN (21-497): 1.22e-12: 74.7: 16.67		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952405 ADNP2_HUMAN (21-497): 1.22e-12: 74.7: 16.67		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		934908 SRCAP_HUMAN (75-749): 9.61e-10: 65.4: 17.69		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952426 SRCAP_HUMAN (75-749): 9.61e-10: 65.4: 17.69		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		152625 KMT2D_HUMAN (37-835): 6.99e-09: 62.7: 9.11		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		152661 KMT2D_HUMAN (37-835): 6.99e-09: 62.7: 9.11		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Sc
		730797 SEC31_YEAST (201-673): 1.92e-11: 70.8: 17.07		CENPA_YEAST (18-134): 2.12e-41: 138: 55.83