HitPredict

Interactor 1: TAF4 (O00268)
Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135)
Gene: TAF4

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1085 Hs			1 726
+	Hs
		124167 TAF4_HUMAN (1-1085): 1.72e-83: 296: 100.00		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		1067077 TAF4B_HUMAN (205-1085): 1.3e-53: 204: 26.30		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		631534 TAF4B_HUMAN (205-1085): 1.3e-53: 204: 26.30		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		1056838 MDC1_HUMAN (4-966): 1.09e-29: 130: 11.32		BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00
+	Hs
		631425 MDC1_HUMAN (4-966): 1.09e-29: 130: 11.32		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		631468 ADNP2_HUMAN (21-497): 1.22e-12: 74.7: 16.67		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		124243 TAF4_HUMAN (1-1085): 1.72e-83: 296: 100.00		KAT2A_HUMAN (267-414): 1.15e-33: 140: 28.86
+	Hs
		124145 TAF4_HUMAN (1-1085): 1.72e-83: 296: 100.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		124240 TAF4_HUMAN (1-1085): 1.72e-83: 296: 100.00		PHIP_HUMAN (5-708): 5.37e-19: 94.5: 10.37
+	Hs
		124165 TAF4_HUMAN (1-1085): 1.72e-83: 296: 100.00		TAF1_HUMAN (23-303): 3.47e-17: 88.7: 13.52
+	Hs
		600199 TAF4B_HUMAN (205-1085): 1.3e-53: 204: 26.30		TAF1_HUMAN (23-303): 3.47e-17: 88.7: 13.52
+	Hs
		998710 MDC1_HUMAN (4-966): 1.09e-29: 130: 11.32		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		554303 MUC1_HUMAN (88-827): 4.92e-29: 128: 12.96		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Dm
		814182 TAF4_DROME (353-1085): 4.03e-38: 156: 25.51		TAF1_DROME (127-721): 9.05e-17: 87.2: 11.55
+	Dm
		814197 TAF4_DROME (353-1085): 4.03e-38: 156: 25.51		Q9VC36_DROME (52-201): 9.78e-17: 87.2: 21.33
+	Hs
		244438 MDC1_HUMAN (4-966): 1.09e-29: 130: 11.32		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		998826 SRCAP_HUMAN (75-749): 9.61e-10: 65.4: 17.69		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		999216 BSN_HUMAN (151-960): 6.8e-09: 62.7: 9.94		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Dm
		532749 Q9VLS7_DROME (1-777): 1.05e-12: 75: 8.49		FSH_DROME (277-481): 4.78e-28: 123: 26.21
+	Dm
		1370354 Q9VLS7_DROME (1-777): 1.05e-12: 75: 8.49		NU301_DROME (36-137): 3.14e-12: 72.4: 38.24