HitPredict

Interactor 1: DP13B (Q8NEU8)
DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)
Gene: APPL2

Interactor 2: DP13A (Q9UKG1)
DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)
Gene: APPL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 25416956, 16189514, 23414517, 33961781, 35271311, 17030088, 28514442, 32296183, 24879834, 18034774, 31515488, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, mammalian protein protein interaction trap, two hybrid array, validated two hybrid, two hybrid prey pooling approach, two hybrid fragment pooling approach, two hybrid pooling approach
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains BAR_3~BAR_3, BAR_3~PH, PH~PH, PID~PID
Common GO terms GO:0001726 - ruffle
GO:0001786 - phosphatidylserine binding
GO:0005634 - nucleus
GO:0005768 - endosome
GO:0005886 - plasma membrane
and 22 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 664
Hs

1 709
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Last updated: 15 Jul 2024